Seclude means to keep a somebody away from other human beings.
While, segregate means to separate. For example, in US History, African Americans were segregated from white Americans.
So seclude is used for one person, while segregate is used for groups of people or things.
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I think the writer is angry
Answer: The despreate trek across america is about, Someone stranded near Tampa Bay in April 1528, without ships or hopes of resupply, Alvar Nunez Cabeza de Vaca and 250 conquistadors, set off on an epic cross-country trek that would leave only four alive.
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