Answer:
As in any debate there were two sides, the Federalists who supported ratification and the Anti-Federalists who did not. We now know that the Federalists prevailed, and the U.S. Constitution was ratified in 1788, and went into effect in 1789.
sign bills which will then become law (if they reduse the Supreme court can make it into a law without the presidents signature)
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The best known statement of the theory of nullification during this period was said by John C. Calhoun