<span>he Streptococcus pneumoniae capsule is vital for virulence and may inhibit complement activity and phagocytosis. However, there are only limited data on the mechanisms by which the capsule affects complement and the consequences for S. pneumoniae interactions with phagocytes. Using unencapsulated serotype 2 and 4 S. pneumoniae mutants, we have confirmed that the capsule has several effects on complement activity. The capsule impaired bacterial opsonization with C3b/iC3b by both the alternative and classical complement pathways and also inhibited conversion of C3b bound to the bacterial surface to iC3b. There was increased binding of the classical pathway mediators immunoglobulin G (IgG) and C-reactive protein (CRP) to unencapsulated S. pneumoniae, indicating that the capsule could inhibit classical pathway complement activity by masking antibody recognition of subcapsular antigens, as well as by inhibiting CRP binding. Cleavage of serum IgG by the enzyme IdeS reduced C3b/iC3b deposition on all of the strains, but there were still marked increases in C3b/iC3b deposition on unencapsulated TIGR4 and D39 strains compared to encapsulated strains, suggesting that the capsule inhibits both IgG-mediated and IgG-independent complement activity against S. pneumoniae. Unencapsulated strains were more susceptible to neutrophil phagocytosis after incubation in normal serum, normal serum treated with IdeS, complement-deficient serum, and complement-deficient serum treated with IdeS or in buffer alone, suggesting that the capsule inhibits phagocytosis mediated by FcÎł receptors, complement receptors, and nonopsonic receptors. Overall, these data show that the S. pneumoniae capsule affects multiple aspects of complement- and neutrophil-mediated immunity, resulting in a profound inhibition of opsonophagocytosis.</span>
The correct answer is a. Position a has the most potential energy. hope this helps
Hey frnd
As water gets warmed up ot expands.
Hope this helps u frnd.
Answer:
A plant’s ability to photosynthesize depends on a variety of factors, including the amount of available sunlight. Plants also go into a protective mode after an environmental crisis, which helps protect the plants’ chloroplasts from damage. During this period, photosynthesis is low. The technique used in this research improved the plants’ ability to recover after a crisis, boosting plant growth and crop yield. This research could ultimately lead to growing crops successfully in different types of environments and in a shorter period of time.
Answer:
Explanation:
Evolution for lack of light. If there is no reason for it you lose the ability but it strengthens other senses. It's compensation. The need to tell if the temperature has increased because of something nearby or ability to feel miniscule movement will increase to compensate for that lack of sense.
