<span>Which one of the following statements does not accurately describe vibrations?
</span>A: Forced vibrations, such as those between a tuning fork and a large cabinet surface, result in a much lower sound than was produced by the original vibrating body.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer:
The water treatment plant does not work properly.
Explanation:
The data from the river samples showed that there was a problem with the water treatment plant because there is high amount of pollutants are present in the river sample. The presence of pollutants in the samples shows that the water treatment plant did not work properly, if they did no pollutants are present in the river water so this presence of pollutants indicates inefficiency of water treatment plant.
Answer:
The elements in increasing order of atomic radius: oxygen, carbon, aluminum, potassium
Explanation:
The distance from the center of the nucleus to the outermost shell of the electron is known as the atomic radius of an element. The atomic radius decreases rightward along each period (row) of the table due to the increase in effective nuclear charge (the charge of the nucleus equal to the number of protons). Across a period, electrons are added to the same energy level and the increasing number of protons causes the nucleus to exert more pull on these electrons, which makes the atomic radius smaller. Atomic radius increases down each group (column) of the periodic table because of the addition of electrons to higher energy levels, which are further away from the nucleus and the pull of nucleus weakens. Another reason for the increase in atomic radius is the electron shielding effect, which is the reduction of the attractive force between a nucleus and its outer electrons due to the blocking effect of inner electrons
While moving from left to right in the second period, c
arbon comes before oxygen and so oxygen will have a smaller atomic radius than carbon. While moving down the periodic table, al
uminum comes before potassium even if they are not in the same period. So aluminum
's atomic radius will be smaller than that of potassium but bigger than that of carbon and oxygen.
.
<span>Adenosine triphosphate, ATP</span>
