Tight-fitting respirators must seal to the wearer’s face in order to provide expected protection. This includes disposable respirators (also called “filtering facepieces”). Therefore, fit testing is required in the US by the Occupational Safety and Health Administration (OSHA) before a user wears a mandatory respirator on the job, and must be assessed at least annually. In addition, fit tests should be performed:
Whenever a different size, style, model or make of respirator is used.
When any facial changes occur that could affect fit, such as significant weight fluctuation or dental work.
A good fit means the respirator will seal to your skin. A respirator can only work when air passes through the filter. Air will take the path of least resistance, so if the seal isn’t there, the air will go around rather than through the respirator – and therefore lessen the protection.
Safety glasses, hearing protection, face shields, hard hats and coveralls can all vie with a respirator for real estate on a person’s face, head or body. For instance, if a half face respirator doesn’t fit well (especially if it’s too large), it can overlap with glasses. The more that happens, the more fogging can potentially occur on glasses, and the more likely it is that they’ll interfere with the respirator’s seal.
Answer:
what is that supposed to mean
Explanation:
C. Radioactivity
is the answer
and Uranium is an element that produces radioactivity
Answer:
Leptin is a protein hormone composed of 167 amino acids of the cytosine family, it is synthesized mainly by white adipose tissue. The leptin receptor is related to that of receptors for cytosines (since it uses Janus or JAK type kinases and STAT-3 proteins as intracellular mediators of transcription pathway), it is predominantly found in the hypothalamus (particularly in the arcuate nucleus and to a lesser extent in the nuclei dorsomedial and ventromedial), hippocampus and cerebellum. There is evidence that leptin acts at the level of the arcuate nucleus, preventing the formation of NPY.
Explanation:
Leptin is produced exclusively in adipose tissue cells in a wide variety of species, including humans, and its concentration is higher in overweight than in lean individuals. The biological actions of leptin can be classified into two groups, those that are exerted in the tissues of the central nervous system, mainly the hypothalamus, and those that are carried out on the peripheral tissues. The former regulate body weight downward, decrease food intake, increase basal energy expenditure and modify some neuroendocrine functions such as reproduction, while the latter have effects on proliferation, differentiation and metabolism of peripheral tissues. The leptin that reaches the hypothalamus, in addition, inhibits protein synthesis and the secretion of neurons producing NPY / AgRP of the arcuate nucleus and stimulates the synthesis and secretion of those containing POMC. NPY (neuropeptide Y) is produced in the hypothalamic arcuate nucleus. This neurotransmitter arrives through the projections of the neurons of said nucleus to the paraventricular nucleus, which is the area where it is released. There are several studies that have shown that an increase in NPY leads to an increase in the sensation of hunger and thus to hyperphagia and obesity. Leptin acts at the level of the arcuate nucleus, preventing the formation of NPY. The leptin receptor lacks enzymatic activity in its intracellular domain. Instead, it is linked to members of the janus kinase family, which belong to a class of tyrosine kinases. The binding of the ligand activates the Jak kinase and leads to the phosphorylation of certain cytoplasmic proteins. Within these proteins there is a class of cytoplasmic transcription factors called signal transducers and activators of transcription (STAT).