The Columbus Exchange was a very negative event that had many impacts on natives for what I can see. A very important and major impact this caused was a spread of a disease called smallpox. This disease infected many people part of their community as lead to death in many causing there population to decline quickly. People have even been said to believe that 90% of the natives who got infected with this disease died which can show that it was very deadly. Lucky we do not have to worry about this horrible disease.
A relationship can be damaged by many things. One is disagreeing with each other. When people don't agree, they damage their relationships by breaking up with each other and divorcing. Another is being abusive. This makes people quickly break up or divorce. But the person being abused may be too scared to tell anyone. I hope this helps! :)