Answer:
The setting influences the plot, which includes the story's events. Certain actions are more likely to take place in specific environments. Also, the story's tone and theme rely on its setting. In addition, the setting shapes the characters.
Explanation:
The answer to your question is A. - Them because you are referring to the crumbs and just not something random, in which case you would use "it".
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Fusion of two germs nuclei
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