Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
In human blood, there is a compound inside the RBCs called haemoglobin which ensures that the muscle will receive enough oxygen during exercise.
<h3><u>Explanation:</u></h3>
In human blood, the red blood corpuscles contain the haemoglobin. Haemoglobin is a iron chelated compound containing porphyrin ring and a globin tail which can establish co-ordinate covalent bond with both oxygen and carbon dioxide. The bonding element depends on the concentration of these two gases. In lungs, where the oxygen concentration is more than carbon dioxide, the haemoglobin bonds with oxygen and brings it to the tissues where carbon dioxide concentration is more. This makes the haemoglobin to release oxygen and bond with carbon dioxide which is brought back to lungs. This is the process by which each and every tissue including the muscles recieve oxygen.
In muscles there is Myoglobin which is another iron-porphyrin compound which has several times more affinity for oxygen than haemoglobin. This helps to extract more oxygen from haemoglobin in muscles.
Answer:
The correct answer is option b. "20 H1, 40 H2A".
Explanation:
Chromatin is a complex that protects and condenses the genetic material comprised of DNA and proteins. When chromatin is in the form of a 30 nm fibril, nucleosomes have a regular positioning along the DNA. This means that each nucleosome is associated with a single H1 molecule. Therefore a chromatin containing 20 nucleosomes will have 20 copies of H1 and 40 copies of H2A, because each nucleosome has 2 copies of the core histone H2A.
