A systematic, rational method of planning and providing nursing care.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
The finding of bowel obstruction in the medical record is most likely the cause.
Intestinal motility is frequently reduced by peritonsillitis, and gas-filled intestinal distension results. It may result in sepsis, multiple organ failure syndromes, or a deadly intestinal blockage if untreated. Given that peritonitis can quickly progress to potentially deadly consequences including sepsis and septic shock, which result in a sharp drop in blood pressure, organ failure, and death, it's critical to have a prompt diagnosis and start receiving the right treatment.
Infection is what causes peritonitis. A hole in your GI (gastrointestinal) tract might allow bacteria to penetrate the lining of your stomach. If you have a burst appendix or a hole in your colon, this may occur. Tertiary peritonitis, an infection or dehiscence at the site of the operation, enterocutaneous fistula, abdominal compartment syndrome, and enteric insufficiency are all peritonitis complications.
Learn to know more about Peritonitis on
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Answer:
What is the standard first aid for a needle stick injury?
1 Wash wound with soap and water
2 Flush out mouth, nose, or skin with water
3 Irrigate eyes with water, saline, or sterile irrigants
4 Report the incident to your supervisor
5 Immediately seek medical treatment at the nearest ER or treatment facility.
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Answer:
ILIIIO8I8IKKKIKIKLKIKKKLKKLKLIKLKLKLKLKLKLKLLOLKLKLKLKL
Explanation:
