1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Anna007 [38]
3 years ago
10

Two protein kinases, K1 and K2, function sequentially in an intracellular signaling pathway. If either kinase contains a mutatio

n that permanently inactivates its function, no response is seen in cells when an extracellular signal is received. A different mutation in K1 makes it permanently active, so that in cells containing that mutation a response is observed even in the absence of an extracellular signal. You characterize a double-mutant cell that contains K2 with the inactivating mutation and K1 with the activating mutation. You observe that the response is seen even in the absence of an extracellular signal. In the normal signaling pathway, does K1 activate K2 or does K2 activate K1? Explain your answer.
Biology
1 answer:
Korolek [52]3 years ago
7 0

Answer:

The order must be K2→K1, since the permanently active K1 allele (K1a) is able to propagate the signal onward even when its upstream activator K2 is inactive (K2i). The reverse order would have resulted in a failure to signal (K1a→K2i), since the permanently active K1a kinase would be attempting to activate a dead K2i kinase.

Explanation:

  • You characterize a double mutant cell that contains K2 with type I mutation and K1 with type II mutation.
  • You observe that the response is seen even when no extracellular signal is provided.
  • In the normal pathway, i f K1 activat es K2, we expect t his combinat ion of two m utants to show no  response with or without ext racell ular signal. This is because no matt er how active K1 i s, it would be unable to  act ivate a mutant K2 that i s an activit y defi cient. If we reverse the order, K2 activating K1, the above  observati on is valid. Therefore, in the normal signaling pathway, K2 activates K1.
You might be interested in
What part of the Respiratory System works as a gate keeper to prevent water and food from going down the trachea?
Alexus [3.1K]
The answer is a i.e. epiglottis.
5 0
2 years ago
What is the color of a mineral in powdered form is the minerals?
V125BC [204]
Is call the mineral's.
7 0
2 years ago
The right and left hepatic ducts emerge from the right lobe of the liver in the porta hepatis and unite to form the:
dexar [7]

Answer:

common hepatic duct

Explanation:

  • The common hepatic duct is formed by the union of the right and left hepatic ducts emerging out from the right lobe of the liver.
  • The right hepatic duct is responsible for draining bile from the right half of the body whereas the left hepatic duct drains it from the left side of the body. 
  • At the junction of the right and left hepatic duct, the common hepatic duct gets formed which then joins the cystic duct and then the common bile duct is formed. 
8 0
3 years ago
How do Earth's interior layers relate to one another and to the surface?
ICE Princess25 [194]
When large pieces of the Earth's outer layer move slowly by plate tectonics, surface features, such as mountains, earthquakes and volcanoes, are formed
7 0
3 years ago
Why are plants important for the survival of other organisms?
Mazyrski [523]
Plants reduce the carbon dioxide (CO2) in the atmosphere and create more oxygen, which is needed by all organisms, through photosynthesis. :)
8 0
2 years ago
Read 2 more answers
Other questions:
  • Why is the nervous system referred to as a communication system?
    6·1 answer
  • Ongoing wave action in the intertidal zone creates which environmental condition that allows for more organisms to survive there
    13·1 answer
  • The waste product of respiration in animals is
    11·2 answers
  • True or False- Cells are grown inside a biosafety cabinet
    13·1 answer
  • What carries amino acids to the site of protein synthesis?
    13·1 answer
  • Movement of the chromosomes during anaphase would be most affected by a drug that prevents mitosis and cell division. What is th
    10·1 answer
  • I NEED THIS QUESTION ANSWERED IMMEDIATELY WILL GIVE MANY POINTS. Question: What is some other information of interest about the
    14·1 answer
  • A cell membrane is more flexible than a brick wall. Why might many cells benefit from a flexible cell membrane? and A building h
    7·1 answer
  • I need help with this waves assessment!!!
    11·2 answers
  • The ___________ inside the bladder is formed by imaginary lines connecting the two ureter openings and the urethral opening.
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!