Answer:
The correct answer is "5-1-3-2-4".
Explanation:
Internalization of LDL particles into cells, is needed to form the intracellular vesicles known as endosomes. The order of events that allow for this process are:
5) LDL receptors migrate to the cell surface and cluster in clathrin-coated pits. Clathrin acts directing the receptors to the cell membrane region where endosomes are formed.
1) A combination of cholesterol and apolipoprotein binds to LDL receptors and becomes internalized as endocytotic vesicles. Once the receptors are in the proper cell membrane region, cholesterol and apolipoprotein are bound and internalized.
3) Several endocytotic vesicles fuse to form an endosome.
2) The environment of the endosome becomes acidic, which causes the LDL to dissociate from its receptor; additionally, the endosome fuses with a lysosome. LDL should be dissociated from its receptor since it is going to be degraded in the following step.
4) The LDL particle is degraded by the lysosome. This takes place after endocytosis, when LDL particles are transported into lysosomes once they are fused, cleaving the cholesterol esters into cholesterol and fatty acids.
1. Enzyme interacts with substrate
.
2. Enzyme may undergo a conformational change to capture the substrate ("induced fit" model)
3. Enzyme-substrate complex may undergo several changes to form the product(s).
4. The product(s) are released
.
5. The enzyme returns to its original form. It is then ready to do the cycle all over again.
It was the trip that Charles Darwin went on in attempt to find the answer of how animals got on earth in the first place and how they changed over time. This later on helped him discover evolution and natural selection. The most significant find on this voyage was that he found that different types of finches evolved to the food around them. Smaller beaks meant the finch ate more small nutrients but larger beaks meant the finch ate more harder prey such as fish and worms.
<h2>Second law of thermodynamics</h2>
Explanation:
- Living organisms are highly organizational and therefore it seems that it feeds from “negative entropy” or, by other words, maintaining and getting to a stationary condition where the entropy level is low.
- Nevertheless it is necessary to understand that the proper definition of the second law of thermodynamics says that the entropy of an adiabatically isolated system never decreases.
- In this context a living cell or organism is not an isolated system, since it gets the nutrients from the exterior, that is, there is an exchange of heat or matter with the environment, and by doing so, we have to consider the system as an open one, together with its environment, restoring the balance to the universe in an increase of entropy, or by other words, increase of disorder.
