Answer:
ICD-Code F43.23
Explanation:
Adjustment disorder with mixed anxiety and depressed mood is one of the six types of the adjustment disorders. This describes the adjustment disorder with mixed anxiety as well as depressed mood as stressor-induced disorder which creates distress personally through symptoms of anxiety and depression both.
<u>ICD-Code F43.23 is billable ICD-10 code used for healthcare diagnosis reimbursement of Adjustment Disorder with Mixed Anxiety and Depressed Mood.
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<u>On October 1, 2018, 2019 edition of the ICD-10-CM F43.23 became effective.</u>
The weather & climate. North India is landlocked while South India is surrounded by the Arabian Sea and Indian Ocean. Generally, weather in the north is cool and dry in winters and hot in summers, with monsoon season from June until mid-September. South India is more tropical with warmer temperatures throughout the year. There is also higher humidity that makes it feel considerably hotter. The winters tend to be driest, with relatively low rainfall between November and April, though Kerala has a secondary monsoon from mid-October thru mid-November.
Answer:
Multiple myeloma is a B-cell malignancy characterized by an excess of monotypic plasma cells in the bone marrow. The molecular mechanisms that are involved in disease progression depend on the interaction between the multiple myeloma cells and the bone microenvironment. Because these mechanisms have been well characterized, it is possible to develop regimens that are more specific to pathways involved in the pathogenesis of multiple myeloma than is typical for conventional chemotherapy in disease management. Thalidomide and immunomodulatory drugs (IMiDs) have now been shown to block several pathways important for disease progression in multiple myeloma. First established as agents with antiangiogenic properties, thalidomide and IMiDs inhibit the production of interleukin (IL)-6, which is a growth factor for the proliferation of myeloma cells. In addition, they activate apoptotic pathways through caspase 8-mediated cell death. At the mitochondrial level, they are responsible for c-jun terminal kinase (JNK)-dependent release of cytochrome-c and Smac into the cytosol of cells, where they regulate the activity of molecules that affect apoptosis. By activating T cells to produce IL-2, thalidomide and IMiDs alter natural killer (NK) cell numbers and function, thus augmenting the activity of NK-dependent cytotoxicity. Data delineating these events have been derived from experiments done in resistant and sensitive multiple myeloma cell lines. Although thalidomide and IMiDs demonstrate similar biologic activities, IMiDs are more potent than thalidomide and achieve responses at lower doses. Lenalidomide, a thalidomide derivative, has also been shown to have a different toxicity profile. Our understanding of the mechanism of action of these agents has provided a platform for exciting clinical trials evaluating combinations of thalidomide and lenalidomide with both conventional chemotherapy and newer targeted agents.
Explanation:
Answer:Epidemiology
Explanation:
<em>Epidemiology is the study of the distribution of diseases and other health related conditions in the population.</em>
After extracorporeal lithotripsy observing tiny fragments in the strainer after voiding which are the remains of the stone that has been passed would be the best indicator that the treatment has been effective.
Extracorporeal lithotripsy is a procedure used to break stones inside the bile ducts, urinary tract, or pancreatic duct using a machine called a lithotripter which produces a series of shock waves that are targeted using X-ray.
A surgeon uses an abdominal X-ray or CT scan to determine whether the treatment was successful or not, using X-ray surgeon can locate any fragment of stone that has remained within the kidney or ureter.
To learn more about X-ray here
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