The Small Cowper Madonna is a painting drawn by the famous Italian artist Raphael, which depicts Mary and Child in a typical Italian countryside. This painting has been dated to around 1505, the middle of the High Renaissance. This picture literally shows the influence of Da Vinci.
If you’re talking only about a standard-tuned 6-string guitar played without any extended techniques, then the lowest pitch is E2, and the highest (depending on the model) is about B5.
