Negative effective like killing most of them but positive because the natives taught them how to hunt and get warm for the upcoming winter but a lot of them fell sick
The north benefited from cotton because when they had built a cotton gin that cotton gin produced a wide spread of cotton to make a great deal of labor but also made the plantation owners use there enslaved people for that task, so without the introduction of cotton gins its possible that slavery would have follows a different course, Im hoping I answers in a way that it is right you
One negative impact would be people or citizens of the Panama would dislike that Indigenous people can come over into the Panama and the trading would extend until free trade without quotas or tariffs.
