Answer:
The order must be K2→K1, since the permanently active K1 allele (K1a) is able to propagate the signal onward even when its upstream activator K2 is inactive (K2i). The reverse order would have resulted in a failure to signal (K1a→K2i), since the permanently active K1a kinase would be attempting to activate a dead K2i kinase.
Explanation:
- You characterize a double mutant cell that contains K2 with type I mutation and K1 with type II
mutation. 
- You observe that the response is seen even when no extracellular signal is provided. 
- In the normal pathway, i f K1 activat es K2, we expect t his combinat ion of two m utants to show no  response with or without ext racell ular signal. This is because no matt er how active K1 i s, it would be unable to  act ivate a mutant K2 that i s an activit y defi cient. If we reverse the order, K2 activating K1, the above  observati on is valid. Therefore, in the normal signaling pathway, K2 activates K1.
 
        
             
        
        
        
50$ or 60$ depending on who you get it from
 
        
                    
             
        
        
        
The combination of compression and high temperature causes the carbon bonds in the organic matter to break down. This molecular breakdown produces thermogenic methane natural gas.
        
             
        
        
        
<span>A population's growth is strongly influenced by the proportions of individuals in different age brackets, which in turn is influenced by economic development.</span>