Answer:
The Columbian exchange, also known as the Columbian interchange, named after Christopher Columbus, was the widespread transfer of plants, animals, culture, human populations, technology, diseases, and ideas between the Americas, the Old World, and West Africa in the 15th and 16th centuries. The impact was most severe in the Caribbean, where by 1600 Native American populations on most islands had plummeted by more than 99 percent. Across the Americas, populations fell by 50 percent to 95 percent by 1650. The disease component of the Columbian Exchange was decidedly one-sided.
Most soldiers died from disease. poor sanitation, battle wounds :)
Throughout history, the ability of practically any government to be able to provide and restore social order is absolutely critical to the success of the state. Are there options to choose from?
More than 50 million people
At the height of its power, the empire controlled by Rome contained about 57 million people and extended over a territory of nearly two million square miles (about 5 million square kilometers). It covered territory throughout much of Europe, as well as stretching into the Middle East and North Africa.