The colchicine substance reduces the enzyme that acts during DNA replication and cell division. With this inhibition, the cell does not go over to interphase stage until the M phase
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Well, in a cigarette, the most active ingredient is ammonia. The companies claim that it enhances the flavor of the cigarette, but, it's actually highly addictive. It allows more nicotine to flow into our bloodstream making us crave more than what we want. But, also in itself, nicotine is also highly addictive, the ammonia just aids it to make the person urge to smoke.