The main reason the US Civil War started because the Northern and Southern colonies had different views on how slavery should be handled. So they went to war to decide.
The Great Plains were one. They hunted elk, bison, antelope, and etc..
While the perpetrator still remains unknown, the US blamed Spain for the explosion, as relations between the two countries were strained over how Spain was mistreating it's colonies in Cuba. This led to the Spanish-American War, which was a US victory that led to the takeover of the Philippines and Cuba from Spain.
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It remade Europe after the downfall of French Emperor Napoleon I and tried to restore old boundaries as well as resizing the main powers so they could balance each other and remain at peace.