Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
For the nurse to develop a lesson plan that is suitable for the client, the nurse must be aware of the client's educational background.
Social support networks are beneficial to have, however they shouldn't be used when a client can understand.
The client's education is the nurse's responsibility; physician consent is not required. Plans for discharge might be created with the assistance of social support networks.
<h3>Do the diagnosis and the treatment match up?</h3>
The diagnostic procedure serves as both a prelude to and a form of treatment in and of itself. Problems with behavior and physical health can both be helped by diagnosis when it is used as a therapeutic tool.
<h3>How crucial are the diagnosis and treatment?</h3>
Your diagnosis serves as the foundation for all possible treatments, including medication and surgery.
In order to avoid wasting valuable time on the incorrect course of treatment, a precise diagnosis is essential. The right diagnosis can only be made with the assistance of the patient.
<h3>What is the problem's diagnosis?</h3>
It is necessary to formulate and test hypotheses in order to diagnose the issue.
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Cri is bad and I tried it I side
The selection of virus variants resistant to the antiviral medicine isoniazid against the herpes simplex virus is caused by prolonged antiviral drug exposure.
<h3>What is a treatment course?</h3>
A courses is a collection of treatment cycles. A therapy program typically lasts between three and six months, but it can be longer or shorter. You would most likely undergo 4 to 8 cycles of treatment throughout that time.
<h3>What are the three types of treatment?</h3>
There are three types of medical treatment, according to theory: Curative: the act of curing a person of a disease. Palliative care is used to treat sickness symptoms. preventive medicine: designed to delay the beginning of a disease.
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Answer:
<u>Ethanol prevents toxicity by competing with Ethylene glycol for metabolism by alcohol dehydrogenase.</u>
Explanation:
Ethylene glycol is an organic compound usually used in antifreeze solutions, solvents and cleaners.
It is abused during self-destruction and accidental intakes.
<u>In the body, ethylene glycol is acted upon by alcohol dehydrogenase and is converted into glycolate and oxalate.</u>
Glycolate and oxalate are both nephrotoxic/ kidney damaging substances. Oxalate precipitates calcium oxalate stones in the kidney. Ethylene glycol poisoning also causes high anion gap metabolic acidosis.
In order to prevent ethylene glycol poisoning, the patient is infused with ethanol, ethanol <u>prevents toxicity by competing with Ethylene glycol for metabolism by alcohol dehydrogenase.</u> In this way, ethylene glycol is not metabolized and the formation of nephrotoxic substances is prevented. Alcohol dehydrogenase instead reacts with ethanol to form acetaldehyde.
