Gradual changes in the frequency of diseases over long periods are known as SECULAR TIME TRENDS. For example, the rate of mortality in USA due to coronary heart diseases over a period of time. Onset of puberty in girls is also a secular time trend.
Secular time trend is also referred as Secular Variation and Secular Drift.
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Unlike natural selection, genetic drift does not depend on an allele's beneficial or harmful effects. Instead, drift changes allele frequencies purely by chance, as random subsets of individuals (and the gametes of those individuals) are sampled to produce the next generation.
The study pushes back the clock on the origin of Earth's water by hundreds of millions of years, to around 4.6 billion years ago, when all the worlds of the inner solar system were still forming. Scientists had suspected that our planet formed dry, with high-energy impacts creating a molten surface on the infant Earth.
Answer: 4.6 billion years.