The false statement is: (a) Transcriptional regulators usually interact with the sugar–phosphate backbone on the outside of the double helix to determine which DNA sequence to bind.
Transcriptional regulator or factor is protein with the ability to control and regulate gene expression at the transcription level by binding to DNA. Transcriptional factors have domain-DNA-binding domain which contains structural motif that recognizes DNA and it is responsible for the attachment to specific DNA sequence. It usually binds to the DNA major groove (hydrogen bonding) because it is less degenerate than that of the DNA minor groove.
Transcriptional factors also contain trans-activating domain for the binding of other proteins and signal-sensing domain for the detection of external signals.
The answer is; C
Plasmids are conferred through horizontal gene transfer in bacteria. The ‘male’ bacteria develops a structure called pili that then attaches to the ‘female’ bacteria. It then transfers it’s replicated plasmid to the ‘female’ bacteria in a process called conjugation. This bacteria will hence have desirable traits that are coded for by the transferred genetic material ,such as antibiotic resistance, after a process called recombination.
A protein kinase that is specific to the amino acids serine and threonine is known as a mitogen-activated protein kinase (MAPK or MAP kinase; also known as a serine/threonine-specific protein kinase).
<h3>Mitogen-activated protein kinase :</h3>
A small number of cell surface receptors can ultimately generate a large intracellular response due to activation of kinase cascades.
In order to trigger an appropriate physiological response, such as cellular proliferation, differentiation, development, inflammatory reactions, and death in mammalian cells, MAPK pathways relay, amplify, and integrate information from a variety of stimuli.
Tyrosine phosphorylation, specifically numerous tyrosines on each RTK in the dimer, is how cross-linking triggers the tyrosine kinase activity in these RTKs. The term "cross-phosphorylation" refers to this action.
The activation of a MAPKKKK or MAPKKK by stimulation of plasma membrane receptors is the initial stage of signal transduction. The MAPKKK then phosphorylates two serine or threonine residues in the S/T-X5-S/T (X is any amino acid) motif of its activation loop, activating a downstream MAPKK.
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Transition from breast or formula feeding until solid food is vital for child's development. Children can learn skills while eating solid food and will be ready to try mashed cooked beans around 7-10 months old. For a 3 year old toddler,it is recommended around 3 tablespoons.
