Answer:The crystal structures of five 6-mercaptopurine derivatives, viz. 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(3-methoxyphenyl)ethan-1-one (1), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-methoxyphenyl)ethan-1-one (2), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-chlorophenyl)ethan-1-one (3), C15H11ClN4O2S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-bromophenyl)ethan-1-one (4), C15H11BrN4O2S, and 1-(3-methoxyphenyl)-2-[(9H-purin-6-yl)sulfanyl]ethan-1-one (5), C14H12N4O2S. Compounds (2), (3) and (4) are isomorphous and accordingly their molecular and supramolecular structures are similar. An analysis of the dihedral angles between the purine and exocyclic phenyl rings show that the molecules of (1) and (5) are essentially planar but that in the case of the three isomorphous compounds (2), (3) and (4), these rings are twisted by a dihedral angle of approximately 38°. With the exception of (1) all molecules are linked by weak C—H⋯O hydrogen bonds in their crystals. There is π–π stacking in all compounds. A Cambridge Structural Database search revealed the existence of 11 deposited compounds containing the 1-phenyl-2-sulfanylethanone scaffold; of these, only eight have a cyclic ring as substituent, the majority of these being heterocycles.
Keywords: crystal structure, mercaptopurines, supramolecular structure
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Chemical context
Purines, purine nucleosides and their analogs, are nitrogen-containing heterocycles ubiquitous in nature and present in biological systems like man, plants and marine organisms (Legraverend, 2008 ▸). These types of heterocycles take part of the core structure of guanine and adenine in nucleic acids (DNA and RNA) being involved in diverse in vivo catabolic and anabolic metabolic pathways.
6-Mercaptopurine is a water insoluble purine analogue, which attracted attention due to its antitumor and immunosuppressive properties. The drug is used, among others, in the treatment of rheumathologic disorders, cancer and prevent
Step-by-step explanation:
Answer:
A. Trinomial
Step-by-step explanation:
It says it's a polynomial and that based on the number of terms. So right then you can cancel out cubic and quadratic because they aren't polynomials. Also:
Cubic is just a variable with the exponent of 3. Examples:
Binomial is a polynomial with 2 terms. Examples:
A quadratic has a division sign.
Perpendicular = opposite sign and reciprocal slope
Make equation into y = mx + b
Add 3y to both sides
3y + 54 = 3x
Subtract 54
3y = 3x - 54
Divide by 3
y = x - 18
The slope is 1
Make it negative and reciprocal
= -1/1 = -1
Solution: the slope will be -1
<h3>Answer: 0.25 dollars (ie 25 cents)</h3>
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Explanation:
The letter T is the 20th letter in the English alphabet. This means that there are 20 letters to pick from to go with the 10 single digit numbers to pick from. We have 20*10 = 200 different combinations (eg: one combination is K4).
Out of these 200 combinations, there is exactly one winning match.
The probability of winning is therefore P(W) = 1/200 = 0.005 and the probability of losing is P(L) = 1-P(W) = 1-0.005 = 0.995 where W and L represent winning and losing respectively.
The net value of winning is V(W) = 250 - 1 = 249 because the player wins $250 but they lose $1 (which is the cost of the ticket). The net value of losing is V(L) = -1, indicating the player has lost that $1 and hasn't gained any money at all.
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To summarize so far:
P(W) = 0.005
P(L) = 0.995
V(W) = 249
V(L) = -1
Multiply the probability P values with the corresponding net values V, then add up the products to get the expected value:
E(X) = P(W)*V(W) + P(L)*V(L)
E(X) = 0.005*249 + 0.995*(-1)
E(X) = 0.25
The expected value is 0.25 dollars or 25 cents
This positive expected value means that the game is favored toward the player, because over the long run, the player gains an average of 25 cents each time they play. On the other side of the spectrum, the lottery company loses on average 25 cents each time. The nonzero expected value means that the game is not fair.
Answer:
Your answer would be (x-4)
Step-by-step explanation:
If you follow the steps of factoring, first you need to set it up. I always start with the term with the variable first.
(x+_)(x+_)
And since we already know one of the factors, we can put that in our expression.
(x+6)(x+_)
Now remember the trick FOIL.
You multiply the FIRSTS together, then the OUTSIDES, then the INSIDES, and finally the LASTS.
To figure out our last blank we us this trick, but backwards. To get the 24 at the end of your expression x^2+2x-24 you multiply the LASTS together. So 6*_=-24. (remember the subtraction sign stays as a negative with the 24) That answer is -4
Hope that makes sense, and good luck!
