A.) 5 years :) because a website said so heheheheh
No, this does not cause any severe problems, despite the unsettling sound. The "crack" you hear is simply the joints releasing built-up gas. It is not bad for your health.
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance. The conditions are referred to as orphan diseases.
There are many challenges which one will encounter while starting a new career but the biggest of them will be that of learning the rudiments of the career. Every field of career has its own principles, tools, techniques and all these have to learned and mastered. For instance, when one is starting out as a nurse, it is always an uphill task to get to know all that is there to know in nursing. One can turn to people who are already successful in one's field of interest for support in this situation. They must have passed through the same situation when they were starting out, so their advice will be valuable and serve as an encouraging platform to start with.