I think you meant to spell Nile instead of Nike... so the civilization that matches with the Nile is Egypt
I believe that the cash crops and the need for those cause a lot of slave trading. Americans used a lot of slaves to help build up cash quickly.
For Philip II, he believes that what was good for Spain would also be good for the Catholic Church. He was so devoted to the Church that whoever is against the Church we would want to persecute them. Philip II himself ordered the Spanish bishops at the Council of Trent to insist on no accommodation of Protestants.
