i think it is the second one
A) A fort was established and many were killed by diseases
Lewis and Clark's expedition was not positive to the native of Mandan village the most devastating epidemic was the smallpox outbreak in the year 1837 killing a lot of people. The epidemic played an important factor in uniting the surviving Mandans and Hidatsa who later engaged in trade, farming and hunting.
Beginning his career as a pastor, Young was an early leader in the civil rights movement, serving as executive director of the Southern Christian Leadership Conference (SCLC) and a close confidant to Martin Luther King Jr.
Answer: Economically the population decrease brought by the Colombian exchange caused a drastic labor shortage throughout America, which lead to the estbalishment of African Slavery on a big scale in the americas.
Is a product? Hope this helped :)