Robert E. Lee moved his troops west after he left Petersburg.
No, it is generally false that countries sought new trade routes to avoid the high prices associated with the Mediterranean, since transporting goods by seas was almost always cheaper and more efficient than transporting by land.
Manifest Destiny played a role in the removal of the Cherokee because people believed it was the United States God given right to expand. This meant the Cherokee needed to leave in order for them to expand their borders westward.
The middle class was different after the industrial revolution than it was before because prior to the Industrial Revolution, Europe had a small middle class. Following the Industrial Revolution, the middle class greatly grew.
After the industrial revolution, the lower classes were been able to "rise up" economically by getting new jobs in factories, thus much of the lower class entered the middle class.