Answer:
The correct answer is ''METAPHASE I.''
Explanation:
Metaphase I is the stage in which chromosomal studies are generally performed, because its morphology is very clear. The chromosomes, moved by the mitotic spindle, are placed in the center, between the two asters and form the so-called metaphase plate, in which the chromosomes are positioned in such a way that the kinetochore of each sister chromatid are oriented towards the opposite poles. Keeping chromosomes on the cell equator implies a balance between the forces of the microtubules that tend to move the kinetochores toward opposite poles, so positioning them in the center involves a great deal of energy.In each kinetochore, between 20-30 microtubules can be anchored, which exert traction force towards the pole from which they come, so the metaphase plate is maintained by the balance between the opposite forces of the poles on the chromosomes, which hold their sister chromatids by centromeric cohesin.
Answer: There is presence of tumor.
Explanation: The adhesion of cells to extracellular matrix (EMC) through integrins ( cell-EMC binding molecules, which are collagens, laminins and fibronectin) causes the activation of kinases in the cytoplasm.
However, kinanes helps in controlling the epithelial cell differentiation and upholding the epithelial tissues. This is done by the addition of phosphate groups to a substrate protein which is termed Protein phosporylation. Then, the kinases direct the affairs of the cell and it's activities. For example, it determines the cell division, anabolic and catabolic activities of the cell, movement of ions between the cell and it's environment (signal transduction), protein functions and etc.
Conclusively, since the activities of the cell like cell division and protein functions is dictated by the kinase, reduction in cell division that gave rise to rapid growth is put on hold. Hence, the tumor is been suppressed.
Note: the binding of cell-EMC is regulated by Transforming Growth Factor (TGF) β.
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