D. Integral
necessary to make a whole complete; essential or fundamental.
I would change the acne off of me.
I know it's simple to not get acne, but when you have it, you can't just wait a couple days and use medicine or stuff to prevent it, you gotta pick at it, and that hurts
1. Safe
2. Dangerous
3. Not sure
4. Not sure
Answer:
subtlety, nicety, hint, refinement. these are the SYNONYMS FOR nuance.
i hope this helps!