The themes that played a major role in changing the world between 1450 and 1750 was that plants were being spread together with animals and diseases between the Americas and the rest of the world; mainly Europe. Especially famous are cases where European contact wiped out whole villages and tribes of native American people because they were unable to cope with the bacteria and viruses.
What illness are you meaning?
This is basically a play or drama written by a man named Schiller in 1804
The 19th admendment says all citizans have the right to vote and
"shall not be denied or abridged by the United States or by any State on account of sex."
"<span>It led to a large number of causalities on both sides" would be the best option from the list, since the war still dragged on although now with far more men involved, meaning more deaths.</span>