When your body develops a tolerance for a medication the body gets used to it being there thus making the medication ineffective.
If he sprained his ankle and you know he's n pain, then you should see the doctor or make an appointment. If the injury is severe then take him or her to the emergency room.
Kyle is definetlyunderweight you can tell even before doing the math. If he is 6 foot and weighs 125 LBS this man needs to see a doctor because he should be atleast 175 which would give him a BMI of 23.7
Physically speaking if one had High self-esteem and a positive outlook you would presume that the individual would be less stressed leading to:
Less chance of heart diseases
Weight loss
more energy
better memory
and the list continues
-hope i helped <span />