Rna is the answer for this
Answer:
Constitutive activation is the alteration of a protein or signaling pathway such that it is functional or engaged even in the absence of an upstream activating event. For example, RasD is constitutively active because it cannot bind GAP and therefore remains in the GTP-bound, active state even when cells are not stimulated by growth factor to activate a receptor tyrosine kinase.
Constitutively active Ras is cancer promoting because cells will proliferate in the absence of growth factors, and thus normal regulatory mechanisms for cell proliferation are bypassed.
(a) A mutation that resulted in Smad3 binding Smad4, entering the nucleus, and activating transcription independent of phosphorylation by the TGFβ receptor would render Smad3 constitutively active.
(b) A mutation that made MAPK active as a kinase and able to enter the nucleus without being phosphorylated by MEK would render MAPK constitutively active.
(c) A mutation that prevented NF-KB from binding to IK-B or that allowed NF-KB to enter the nucleus and regulate transcription even when bound to IK-B would render NF-KB constitutively active.
Answer:
Acids or bases can be tested by chemical indicators.
Explanation:
A chemical indicator can be described as a paper substance which changes colour when dipped in an acidic or basic solution. It can be described as a chemical indicator for hydrogen ions (H+) and hydronium ions (H3O+).
Acidic solutions normally dive red-orange colours depending on the acidicity of the substance. The basic solutions give blue-violets colours depending on the basicity of the substance.
Answer:
a)
Based on the data for the group of cells, among the four proteins, protein p16 does not appear to play a role in blocking cell cycle entry by fibroblasts. The evidence for this is in group 7, where, in the absence of the other proteins the p16 presence has helped the replication of DNA almost as good as the growth in the 10% serum.
In the other groups (3 to 6) the presence of any other protein has always inhibited the DNA replication compared to the fibroblast in 10% serum.
b)
Groups 4 to 7 have higher chance of including cells undergoing mitosis as they are showing more DNA replication compared to the group 1 which has 0% serum. In this group since it has been cultured for 48 hours in the absence of serum (serum-starvation), they stop dividing and enter the G0 stage of the cell cycle.
c)
The data here would provide the crucial information on which protein is required to induce the cells to enter the cell cycle. To recover from an injury the cells should divide and repair the wound, this will happen through stimulating the cell with the required protein. It would also shed light on which protein would inhibit the cells from entry into the cell cycle.
Note: Figure is added in the attachment section
Answer:
newton's laws rely on the fact that gravity will bring an object naturally down.
Explanation:
the weight of any object determines the force it has when falling
