The earliest you could call them would be 11:00 am, central time zone
Explanation:
The question is incomplete.
However a standard method to dertmine how workload effects health is developed and is called Harvard step test.
The Harvard Step Test is a fitness test method devised to measure heart and respiratory fitness. It is done by giving some work load to a person for 5 minutes (normally) and then noting his heart rate afterwards in some intervals.
Formula is;
Fitness Index = (100 x test duration in sec) / (5.5 x pulse count between 1 and 1.5 mins)
True.
The word Mesopotamia means between the rivers. Mesopotamia is nestled between the Tigris and Euphrates Rivers and forms the eastern half of the Fertile Crescent. Early civilisations showed up about six thousand years ago.