Vaccines are a boon in eradicating various lethal diseases and increase the immunity of the people. The development of vaccines started with the understanding the cell itself, various pathways that regulate its fate. The immunology, a branch of biological science, gave the idea of the working of the defense or the immune system of the body, and of the various specia cells that function for it. This led us to the discovery of antibodies and antigens. Vaciines are artificial means of injecting antigens into the body to generate antibodies beforehand, so that the immune system remembers producing it at the time disease causing agent strikes us.
Thus, we can summarise that STEM research or core science research has led to innovations that have shaped our lives and lifestyle to contribute to an overall good social health.
Answer:
a) There are lots of genes on chromosome 1 could be affected, and the gametes could be imbalanced (missing segments of DNA or whole chromosomes)
b) Roughly 50%
c) No. I would advise that the couple undergo preimplantation genetic diagnosis, so that a zygote carrying the normal copy of chromosome 1 could be selected.
Explanation:
Chromosome 1 is one of the largest and most gene rich chromosomes. An inversion that covers 70% of its length would cover lots of genes.
While an inversion on its own would not seem problematic (as all the genes on the chromosome are still there), when it comes to meiosis, the sister chromatids would not be able to correctly align, and crossing over would further complicate this. It could also lead to unbalanced gametes missing entire parts of the chromosome. Therefore, there are likely numerous genes that will be affected and messed up by the inversion.
This could explain the high incidence of past still births, as if lots of genes are affected, and non-functional, the pregnancy would be rendered non-viable, or highly deleterious causing premature death.
b) There is a 50% chance of a child inheriting the defective copy of chromosome 1 (and 50% of a chance of them inheriting the normal chromosome 1. Therefore, there is likely a 50% chance that future offspring would be affected by defects
c) No. I would advise that the couple undergo preimplantation genetic diagnosis. In this, the couple undergoes in vitro fertilization (IVF). When embryos are produced through IVF, they can then be tested for the presence of the abnormal chromosome. Embryos will only be implanted into the mother if the normal chromosome 1 is present.
Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body. Chromosomes are structures within cells that contain a person's genes. ... A trait is any gene-determined characteristic and is often determined by more than one gene.
