I'm not sure if you made a typo or not but in the current context I can only see negligible being relevant.
The answer is:
It will call on Americans to act instead of acting for them.
It will challenge Americans instead of protecting them.
The new deal is a set of government programs that is aimed to provided government funded help to address the great depression. But the unemployment still remain high years after the new deal and it increase united states debt, so it has to be ended.
The new frontier program was proposed to fund projects for space exploration. Kennedy believe that this is different from the new deal since it actually challenge American to learn and contribute rather than waiting around for government help
