Answer:
ionic, hydrophillic,polar
Explanation:
non polar compounds dissolve in non polar solvents like alcohol and hydrophobic substances generally repel water .
Answer:
Channel proteins and Carrier proteins
Explanation:
These are type of membrane proteins that transcend the entire length of phosphoslipid bi- layer in the plasma membrane.They facilitate the movement of ions and molecules across the walls of the plasma membranes.
Generally, substances like glucose, amino acids, are too large to pass through the phopholipid bilayers. Likewise ions of potassium, sodium calcium, because of their polarities can not pass through either. They are ferried across the phospholipid by group of protein structures called channel proteins. Some are also transported across by carrier proteins. The process by which these protein structures aided the diffusion of substances across the phospholipid bilayer is called Facilitated diffusion.
Channel proteins are pores, that are filled with water molecules with the entrance well gated. That is the entrance is controlled by part in the inner structure of the protein which can open or close the pores like a gate to control the movement of ions across it. e.g Sodium channels are gated for movement of sodium ions by voltage or ligands(chemicals) during nervous transmission to elicits action potential. Like wise Potassium channels allow diffusion of potassium ions across the phospholipid bilayers. it gates are shut when sodium channels are open; this regulate ion exchange.
Their structures are well fixed in shape , specific to the substance or ions being transported;and the rate of diffusion depends on the like hood of opening of the gate or closure.
Carrier molecules also in the membranes do not have a fixed shape, and their transport direction is determined by the direction of concentration gradients. Thus they can flip on either sides of the membranes to aid diffusion across. Their movement can be both passive and active, and the rates of diffusion depends on the number of available carrier proteins in the membrane. They are also specific to the ions they transport.And are not gated,
Therefore these two membrane integral proteins facilitate movements of substances across the phospholipild bilayers
Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Answer:
Cells are considered the basic units of life in part because they come in discrete and easily recognizable packages. That's because all cells are surrounded by a structure called the cell membrane — which, much like the walls of a house, serves as a clear boundary between the cell's internal and external environments.
