Friendship is one of the most powerful and strong yet fragile things on earth.
Explanation:
Friendship is one of the most powerful and strong yet fragile things on earth. <u><em>For example, if you and one of your friends has a secret that's super important to you, the other person has the power to leak it or tell someone else.</em></u><u> </u>That's what I mean when I sayfriendship is one of the hardest but most fragile things in the world.
The first one is the correct way to use it, since it separates the parts of the sentence into fragments that can still be understood without changing the meaning of the entire sentence.