If you are looking to answer this question I recommend researching how the US has adapted to the land we live in, how land features, water features, climate, location, and resources affect our economy and use of land. For example, the Mississippi river allows for national movement of goods as well as tourism both of which affect our economy.
Cotton Gin was a technological development that led to an increased demand for slaves in the United States during the early - mid 1800's. The cotton gin made it easier to separate seeds from the cotton - making it faster to pick cotton!
The first animated series produced for prime-time network network television was The Flintstones. The series was not the very first animated series overall, hence the Guinness World Records state it as "first for prime-time".