There are 20 amino acids and 64 codon combinations that make up an amino acid, therefore some amino acid combinations result in the same amino acid.
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Osteoarthritis in the lumber vertebrae is caused due to degenerative disorder or due to injury in the backbone/cartilage. The high rate of lumber vertebrae osteoarthritis indicates the presence of genetic disorder only, which means the Native American tribes carried a gene for this disorder, which was only expressed in the female offsprings.