Be healthy I think I really ain't sure
Dermal formulations can be used for a number of different skin conditions, some such as Eczema or Rosacea.
Either Mario's social skills or Mario's fine motor skills
If you are aware of the expiration dates then you'll know when it has spoiled or how much time you have left.That way you aren't drinking something spoiled or eating something half rotted.
Stage 1 tumor would most likely present the best prognosis