Answer:
I spent the time playing gin rummy with Timothy. I looked over a few times at my mom, <em><u>however</u></em>, to make sure she was doing okay.
Explanation:
In the given excerpt from "Astro-Dad", the narrator described the moment his family, and others, watched as his father left to go to space. And at that moment, he also revealed how he took care of his brother and still checked on his mother.
Now, the use of the word "though" in this excerpt is an adverb to talk of his action of checking on his mother while also keeping his younger brother occupied. And in replacing the adverb with "however", the meaning remains the same.
Thus, the correct replacement is "however".