I believe the answer is: B-it was located at a crossroad for trade between Asia and Europe
This location massively contributed to the vast amount of wealth that the Constantinople made through trading. Commodities from Asia such as spices and silk could be sold at a really high margin to the consumers in European Empires.
Cowboys spent over 12 hours in the saddle, they suffered from rheumatism, damage to their spines and a wide variety of injuries related to their work.
