Some possible negative effects from the creation of printmaking are:
1) The waste of trees. Printmaking requires paper and paper is made from trees. This aspect could have negative effects on our environment over a long period of time.
2) Agricultural shift. In order to create paper, trees need to be cared for. This caused a shift in agriculture by having farmers leave farming of food and join the forces of farming trees for paper. Less food being produced is a result of this.
3) Injuries and working conditions. When printmaking first became a thing, the working conditions weren't all that great. Many people could've gotten hurt from the printmaking machine or from external factories (like working in a warehouse) with the machine.
As it is very different to what most play writers (not sure if correct word) would write about. it showed and developed ideas that people weren't use to seeing on stage making it very different.