The main issue is SLAVERY. If Missouri is approved as a state, there would be more states that practices slavery or ownership of slaves than there are none.
They wanted to keep the number of slave states and free states equal. Initially, there were 11 slave states and 11 free states. If Missouri is accepted as a state, there would now be 12 slave states. Government leaders fear that the balance of power would be in favor of those slave states and they will have a run on the federal government. These concerns were solved under the Missouri Compromise and Missouri became a slave state in 1821.
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Rural, low density advanced technology
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environmental factors such as resources available
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A Margin Requirement is the percentage of marginable securities that an investor must pay for with his/her own cash. It can be further broken down into Initial Margin Requirement and Maintenance Margin Requirement.