The Florida Purchase Treaty.
Social,Economic and Political Differences Between the New England and Chesapeake Colonies. Nations quickly colonized the New World years after Columbus so called discovery. England in particular sent out a number of groups to the east coast of the New World to two regions.
This is a bit subjective, but it could be argued that social change had the biggest change in Southern life, since the abolition os slavery (which was inherently a social issue) led to the biggest changes.
Engel v<span>. </span>Vitale<span>, 370 U.S. 421 (1962), was a landmark United States </span>Supreme Court case<span> that </span>ruled<span> it is unconstitutional for state officials to compose an official school prayer and encourage its recitation in public schools</span>