The proteins are produced in the golgi apparatus. Then, they are transported through the microtubules inside the cell towards the cell membrane. Then, the proteins pass through the lipid bilayer of the membrane. of the membrane and move out of the cell.
If the Na+ voltage-gated channels in a muscle cell open, the Na (sodium) ions rush inside the muscle cell and makes the cell more positive as Na ions carry positive charge on it. Due to the entry of positively charged ions inside the cell, the cell becomes less negative and more positive. This is called depolarization of cell.
The failure of homologous chromosomes to separate properly is during meiosis where mutation appear