Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
The first argument listed after IF
Explanation:
When the two variables are listed next to each other, Excel will find and calculate the correlation between them.
Answer:
The answer is "SPAN"
Explanation:
The full form of SPAN port is "Switch Port Analyzer", which is used to designed specifically for the interface on a network device, that would be able to monitor all traffic passing across the entire device.
- The use of this port will also call the mirror ports, that is a popular way of gathering data traffic for tracking purposes.
- It is primarily used to access the bus switch and all interfaces, which is usually accessible from data transmission.
Answer:
Data sequencing is the sorting of data for inclusion in a report or for display on a computer screen.
Explanation:
