Declaring that the Old World and New World had different systems and must remain distinct spheres, Monroe made four basic points: (1) the United States would not interfere in the internal affairs of or the wars between European powers; (2) the United States recognized and would not interfere with existing colonies and dependencies in the Western Hemisphere; (3) the Western Hemisphere was closed to future colonization; and (4) any attempt by a European power to oppress or control any nation in the Western Hemisphere would be viewed as a hostile act against the United States.
The Great Compromise of 1850 was 5 laws that surroundsd the issue of slavery and expansion of territory. It did not regulate slavery in California and also strengthened the Fugitive Slave Act, which made Northerners return slaves to the South after making their way to freedom.