Physical signs : Headache
Emotional signs : Happy,guilty,
Behaviour signs : loss of interest, personality
I believe the answer is E. d41 because it goes a11, A12, b21, B22, c31, C32, then it goes lowercase d41 and then the next one is going to upper case D42.
Hope this helps.
None of these is a major city in the United States.
Skokie, Illinois
Del City, Oklahoma
Harbin, PRC
Pittsford, New York
Hobart, Indiana
Kfar Tapuach, Israel
Stafford, Texas
Armagh, Pennsylvania
Dinwiddie, Virginia
Flora, Illinois
Olathe, Kansas
Mexico City, DF, Mexico