It had a negative impact on the Native Americans, because the settlers were taking over the Native's land and livelihoods. As more Europeans came, the Natives were forced further and further from their tribal lands.
Native peoples of America had no immunity to the diseases that European explorers and colonists brought with them. Diseases such as smallpox, influenza, measles, and even chicken pox proved deadly to American Indians. Europeans were used to these diseases, but Indian people had no resistance to them.
