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<span>B.They often showed alphabets, numbers, poems, sayings, names, and birth dates.
C. They had borders with pictures of houses, birds, flowers, or trees.</span>
The themes that played a major role in changing the world between 1450 and 1750 was that plants were being spread together with animals and diseases between the Americas and the rest of the world; mainly Europe. Especially famous are cases where European contact wiped out whole villages and tribes of native American people because they were unable to cope with the bacteria and viruses.
I might be wrong but I believe it was Afghanistan...?
The main cause of death in the civil war was disease.
Clothes were not clean
Food was not sanitary
It was not a fun place
